When asked whether there is a better striker in Europe than Kane at the moment, Wenger replied: "If you look at the numbers, no, because he has high numbers but I believe what you want in a game like that is to keep him quiet and for our strikers to express their talent."
Arsenal - - overcame Tottenham at the Emirates Stadium earlier in the season but sit four points behind their fifth-placed neighbours in the Premier League.
But Wenger is optimistic his side can make up some ground on Spurs, as he said: "We want to win this game, we have a good opportunity and we want to take it.
"It's a big game because we are behind in the table and we have to catch up.
"It is more important for us to come back mathematically than it is emotionally-charged."
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Wenger will make a late call on his goalkeeper, with first choice Petr Cech a doubt for the Wembley clash because of a calf injury he suffered in Arsenal's 5-1 win over Everton last weekend.
However, Wenger has full faith in back-up Colombian custodian David Ospina.
Wenger added: "We had some problems with Petr Cech and we are not sure - he hasn't practised.
"I will not take any risk if he is not 100 per cent because I have full confidence in David Ospina.
"David Ospina or Petr Cech, I will make that decision tomorrow."