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It has been over a year now since these two were Sky Bet Championship teams and a lot has certainly happened on the field in that time. Sheffield United have been the surprise package of the season, while big-spending Villa have 10 huge games left to try avoid an immediate return to the second tier.
This will be the first chance to see the effect (or lack of) of home advantage in the Premier League and how both sides react. Dean Smith's side have collected 71% of their points this term at Villa Park, although being without the hope and expectation of their own support may actually take the weight of expectation off their shoulders.
At the opposite end of the scale, Sheffield United have been one of the league's most impressive sides on the road. They thrive in the role of the underdog and travelling to an empty ground may, as bizarre as it sounds, just hinder them ever so slightly.
Villa had lost four on the bounce going into the enforced break and the time off should actually have benefitted them, as Alex Keble notes here in his Premier League predictions.
That extra time has given Smith, John Terry and the other coaching staff a chance to wipe the slate clean and work on various tactics with an expensively-assembled squad that should have been clear of danger.
More important for them is the return of John McGinn. The Scotland playmaker was arguably one of their top performers in the first half of the season before suffering a fractured ankle in December.
A lot is said about Villa being a one-man team with reliance on Jack Grealish, but scratch the surface and McGinn is just as important and he is back fit going into the final run-in.
The 25-year-old has scored three goals, assisted two more and got WhoScored's Man of the Match award four times in 18 league appearances, as well as scoring another seven for Scotland this term.
He averages two shots per game across the course of the campaign and his return will give Villa a huge lift. Considering the threat he poses in the final third, he is available to score anytime at an appealing 19/4.
The 4/5 available on him to get one effort on target was tempting, but the goalscorer price on a player with McGinn's qualities and eye for goal looks too good to pass up.
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