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The first of the two 'heavyweight' clashes sees Atletico Madrid take on a Juventus side fancied by many for success in this competition.
We're looking elsewhere though, with the 22/1 price on Atletico lifting the trophy backed in our outright preview.
You can read that full piece here, but the explanation behind the recommendation points towards the changes made in personnel over the summer:
Atletico have gone agonisingly close to a Champions League trophy on two occasions under Diego Simeone. The first being in 2013/14 and then again in 2015/16 where they reached the final.
Both games ended in defeat in the final, both of those defeats were handed to them by Real.
In the three seasons since, the showings we've seen from Atletico have not reflected those of the quality squad they have possessed.
The round of 16 defeat to Juventus last season will still hurt. A 2-0 success at home was followed by a 3-0 defeat away; sentenced to defeat when it seemed victory was so likely.
They would go onto finish second in LaLiga though which, on the whole, is another big positive in Simeone's reign.
This summer has been one of significant change though, and based on very early showings in the league, there is every chance Atletico will see more silverware this season.
Iconic defender Diego Godin has departed for Inter, Antoine Griezmann made the switch to Barcelona, Lucas Hernandez completed a big money move to Bayern Munich and holding midfielder Rodri is now at Manchester City.
Atletico reinvested the money though. The highly-rated Joao Felix joined for an eye-watering €126m fee. Marcos Llorente comes into the midfield, so too does Hector Herrera, while Kieran Trippier and Mario Hermoso fill the voids left in the defensive areas.
Atletico fell to a surprise defeat away to Real Sociedad at the weekend, but their LaLiga campaign had got underway with three victories prior to the international break.
The results at the Wanda Metropolitano Stadium will be key for chances of success in all competitions this season. They accumulated 48 points in front of their own fans in LaLiga last season, matching Barcelona at the top of the home standings.
They'll carry that home form into Europe - and the 6/4 price on Atletico wrapping up the three points is worth taking.
Best bet:
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Odds correct at 1250 BST (16/09/19)
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