It's not the fixture Tottenham would have wanted when needing victory to secure passage in the Champions League but Mauricio Pochettino's men head to the Camp Nou aiming for a positive result.
Spurs sit in second in their group, but the fact that Inter host bottom-placed PSV highlights how the advantage is firmly with the Serie A club.
However, Tottenham do beat Inter when it comes to head-to-head away goals, and therefore will progress if they match Inter's result points-wise.
It was a highly-entertaining encounter when these two met at Wembley, with Lionel Messi starring once again as Barca ran out 4-2 winners.
Tottenham's results have improved since that game though with two wins and a draw, and I don't buy into the argument that they have 'no chance' in Spain on Tuesday night.
Pochettino's side have the best away record in the Premier League with 24 points gained from a possible 30. In comparison, Manchester City have only managed to gain 17 points (although they have played two games less, but even two victories wouldn't match Spurs' record).
Harry Kane will be fresh for this one having only played 15 minutes in their 2-0 win over Leicester at the weekend, and I am a huge fan of the 7/2 available on him to have two or more shots in this game.
Kane has managed to hit that criteria in his last four Champions League encounters. He had two in their last meeting with Inter, a total of seven across two games against PSV and, most importantly, two shots on target in their home defeat to Barca.
Spurs can't rely on favours from PSV given their form so far and will have to look to take their opportunities. The striker leads the way for shots taken by some distance, his 51 in total significantly more than the 24 taken by Son Heung-Min in second.
Alongside that, the 3/1 general price on a draw looks tempting too given the permutations. Despite their quality, Barca have proven that they can slip-up in front of their own supporters this season and the Premier League's best away team can capitalise.
Best bet:
Best bet: