I don't think it's overstating it by calling this a monumental game for Villa, who probably thought they were definitely down before pinching that glimmer of hope with a win over Palace - and now face another mid-table side with nothing to play for.
Except, however, that this Everton mid-table side just got embarassed at Wolves and will have learnt a lot of more colourful Italian language from Carlo Ancelotti this week. They're currently 11th and the players must know by now that 11th is the worst the club having finished since escaping relagtion in 2004.
Ancelotti and captain Seamus Coleman both slammed the attitude on Sunday, and surely professional pride will mean a raised level of performance - without a crowd though, can they match Villa's intensity? If they can, then they have more than enough quality to win.
READ: Should England still pick Pickford?
And winning two games in a week is a big ask for a Villa side who won for the first time in sixth months on Sunday. With Watford playing West Ham on Friday though, a win here would really give them a fighting chance - especially as they play the Hammers on the final day.
Colour me sceptical but I'm just not convinced Villa are set for some miraculous escape, and I'm not convinced Everton will serve up two stinkers back-to-back with Ancelotti in charge. Villa will come flying out at this one, but their defence has been rotten this season - conceding in every away game.
The shades of odds-against on an Everton win is worth taking, as quality should count here - if they fail again then a few of them shouldn't even bother turning up at Goodison next season.
Prediction: Everton 2-1 Aston Villa
Best bet:
Caglar Soyuncu is suspended while James Maddison and Ben Chilwell are out for the Foxes who are seeing their Champions League dreams melt away on the back of that bizarre defeat at Bournemouth. How they conjured up a defeat there is beyond me.
The improving Blades can actually close to within two points of struggling Leicester who, despite winning just four games this year, can still make the Champions League if they win their last three games. They're 4/11 to miss out to Chelsea and Man Utd though.
Best bet:
That late Southampton goal was a sickener for United, even though Saints probably deserved a point, but they've got a friendly fixture to get back on track in what looks an inevitable top four finish for them.
Palace resumed with a win that put them on 42 points, then seemingly went on their holidays with five defeats since then - so you can see why United are huge favourites to continue their fine form here.
Palace, who haven't beaten United at home since 1991, have drawn four blanks in their last five defeats, with over 2.5 goals coming in three of them, while United's last five league games have all eclipsed that number.
Over 2.5 is 8/11 here, and Man Utd to score three (11/8) is another avenue worth exploring after Palace conceded three against Leicester and Chelsea and four against Liverpool - United just have so much pace and clinical finishing ability that anything other than maximum effort defensively could keep them out - and Palace simply won't have that for 90 minutes.
Prediction: Crystal Palace 0-3 Man Utd
Best bet:
One for the teamsheets this one, as although Southampton are on a great run Ralph Hasenhuttl may have to make changes after his boys put a tremendous shift in at Old Trafford roughly 72 hours before they kick-off here.
Danny Ings will want to play and try and cling on to his fading Golden Boot hopes, and he has a canny nack for scoring first - as have Saints lately having taken the lead in each of the last four games - all in the first half.
Best bet:
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