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There's no Paul Pogba for Manchester United, but he may well have been rested anyway as Sunday's Premier League game at Newcastle is now far more important - although it's a real problem for Ole Gunnar Solskjaer as he can't really afford a slip-up in the Netherlands either.
Making changes, however, has not gone too well for Solskjaer as his side limped to wins against Astana (1-0) and Rochdale (penalties) and more turgid stuff like that will only increase the building pressure on his shoulders. He needs an exciting performance and a few goals to lift the gloom.
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Lazio started their group campaign with a defeat at Cluj and they will fancy their chances against Ligue 1 side Rennes at Stadio Olimpico.
Rennes are in their second successive Europa League campaign, drawing with Celtic last time out, and they are without a win in their last six in all competitions.
Lazio had a poor three-game winless run but have bounced back with two wins from their last three, including a 4-0 thrashing of Genoa at the weekend.
There is a noticeable trend with Lazio starting quickly this season, with goals in the first 10 minutes in their last two home games and three other goals coming in the first 25 minutes.
With this in mind, Lazio have the firepower to get the better of a Rennes side on a poor run and lacking in confidence, with the 19/10 price on the hosts to be winning after half an hour a favourable option.
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Odds correct as of 1700 BST on 2/10/19
2000 BST kick-off unless stated