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The Blades are back in the big time and they've got a huge chance to kick-off their home campaign with three points against a flat looking Palace side who will be desperate to have Wilfried Zaha starting and fully focused on his Eagles future.
United were the best Championship side at home last season but Roy Hodgson's men were experts on the road, winning 29 of their 49 points away from home and with talisman Zaha scoring nine of his 10 goals away from Selhurst Park.
Zaha has also bagged six in his last seven away games so if he's on his game then he, and Palace, will be a real threat on the break if the Blades are too gung-ho in front of what will be a buoyant Bramall Lane crowd.
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What a first week in charge it's been for Frank Lampard, getting hammered at Old Trafford then losing to Liverpool on penalties in the early hours of the morning over in Turkey in the Super Cup - welcome to life as a Premier League boss!
It won't always be as tough as that with a talented Chelsea squad, but Sunday sees another tricky assignment as Brendan Rodgers brings his well-fancied Leicester side to town for Lampard's big homecoming at Stamford Bridge.
The Foxes won this fixture 1-0 last season but that was a rare loss for Chelsea against these opponents, and despite results going against them there have been plenty of positives to take from Lampard's first two games in charge - plus he has senior players returning all the time to help his younger charges.
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