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The other tie also sees one team hold a slim advantage, although Leeds have the bonus of playing the second leg at home.
Kemar Roofe's goal was the difference as they won 1-0 at Pride Park. It was a game filled with controversy, particularly when Derby were awarded a penalty before it was overturned. In the end, it looked like the officials had made the right decision.
One other thing from the first leg is how there were a few incidents that could have been red cards on another day. Fikayo Tomori, Mateusz Klich and Tom Huddlestone all could have been given their marching orders.
It's worth keeping an eye on the odds for a red card when they become available, based on what we saw in the game on Saturday. Anthony Taylor may have a different view to Craig Pawson if we see a repeat.
Leeds have spoken about avoiding complacency and they'll need to do the same given the attacking threat that Derby possess. Whether Martyn Waghorn recovers remains to be seen, but it could mean a repeat of the first leg where David Nugent starts up front with Harry Wilson and Tom Lawrence looking to play off him.
Roofe was to be the tip to find the net in this one, given his record so far and the fact he would have retained the striker position in favour of Patrick Bamford - who returns from suspension.
Roofe, however, has been ruled out through injury and that has made Leeds' task that little bit tougher given how important he's been in the big games.
Instead, it's worth considering Mateusz Klich at a price of 4/1. The midfielder has proven his attacking qualities with ten goals and has started every single league game.
Score prediction: Leeds 1-0 Derby ()
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