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We may have only just passed the halfway mark in the 2018/19 Premier League season, but Thursday's match will go some way to telling us where the title is going to end up.
Pep Guardiola's City are currently seven points behind Jurgen Klopp's Liverpool, and a 10-point gap at this stage of the season would represent a significant blow to the reigning champions. As well as being a considerable gap to bridge at the best of times, it would hand Liverpool a mental edge which has proved so important over the years. Conversely, should City win then Liverpool's wide leap would suddenly appear narrow.
Tottenham are second and still in the running, but yet to be taken quite so seriously despite the consistency of their performances under Mauricio Pochettino in recent seasons. Rightly or wrongly, Thursday's match will be considered by many to be a title showdown.
Liverpool made a good start to a testing week by hitting five against Arsenal and they will travel to the Etihad hoping to avoid defeat to continue their unbeaten season and put them firmly in the driving seat at the top.
Guardiola's side have won just one of their last four in all competitions, leaving them playing catch up, and the mind games have already started between the two managers.
Best bets:
With preference to avoid the results market, there is real value in the shots betting and this particular option caught the eye with odds above 2/1. The two Liverpool forwards were on target in the victory over Arsenal and given that chances are expected for both teams, a shot on target each for Firmino and Mane is not much to ask. Four of Firmino's five shots against Arsenal were on target, so confidence will be high after his hat-trick, while both of Mane's two attempts in the same game were on target.
With similar reasons as above, the price for these two looks excellent considering the two forwards should lead the line for their team. Aguero's record against Liverpool at the Etihad speaks for itself - scoring in all six of his home league appearances against the Merseysiders - while Salah has a tendency to shoot when he gets sight of goal and averages over three shots per game, so at these odds it is worth a small play.
Sporting Life Price Boost: Both teams to score in the second half -
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Odds correct as of 1500 GMT on 02/01/19