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There's precious little between these two sides, with United just favourites after an extra time win against Copenhagen in the last round, when Bruno Fernandes scored their 21st penalty of the season to get them through.
Raul Jimenez missed a penalty for Wolves as Sevilla dumped them out, but the Spanish side deserved to go through on the night and produced a more complete performance than Ole Gunnar Solskjaer's side, especially considering their respective opponents.
There aren't many goals around when five-time Europa League winners Sevilla are playing - they had six 'wins to nil' in their last eight games and in this competition they've only conceded three goals all season.
The has its name written all over this and if you're going a step further then the 0-0 after 45 minutes has to be on the shortlist given the cautious nature of these one-legged ties at this stage.
Oh, and the stats to support this aren't too bad either - with seven of Sevilla's 10 Europa League games being goalless at the break, along with three of their last four games in all competitions.
United hold their own in this category too, having been 0-0 at half time in their last three games straight, while also keeping a first half clean sheet in their last four European ties. If there's action, it'll be in the second half, bringing our old favourite squarely into play.
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Odds correct as of 19:32 BST on 14/8/20
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