It's the big one of the weekend and about as intriguing as big games get as Manchester City go into the game in unfamiliar circumstances, coming off a bad defeat and sitting in fourth in the table - looking up at Chelsea a point above them.
City's defence was a shambles at Anfield and, as good as they are going forward, if they're that bad against Frank Lampard's flying Blues then they'll have their hands full again. Chelsea have won six on the spin in the league and are the top scorers on the road - while nobody has scored more at home than City.
Everywhere you look there are goals - amazingly Chelsea's away games average five goals per match this season, and with Tammy Abraham, Mason Mount and Christian Pulisic all looking dangerous they'll fancy their chances up at the Etihad.
City always seem to score though, and Pep Guardiola normally gets a response out of his side after a loss, although he's had a little too much practice of that this season already. It's tough to call, and 5/1 on a Chelsea win looks huge given the run they're on, but preference always has to go to City at home - probably even more so when they've a point to prove.
So while we're not quite confident enough to predict a Chelsea win, there's at least a goal here for them, maybe more, and with City coming flying out of the traps, that goal could well come on the break early, in what we're anticipating to be a breathless first 45 minutes.
Prediction: Manchester City 3-1 Chelsea
Best bet:
Key stats
Alex Keble looks at how the tactical battle between Frank Lampard and Pep Guardiola will be played out in Manchester City's clash with Chelsea. Click the image below to find out more
Best bet:
Key stats
Best bet:
Key stats
Jose Mourinho is the new manager of Tottenham - Dom Newton-Collinge, Tom Carnduff and Paul Higham sit down to discuss the appointment.
Best bet:
Key stats
Best bet:
Key stats
Best bet:
Key stats
Best bet:
Key stats
Best bet:
Key stats
We are committed in our support of responsible gambling. Recommended bets are advised to over-18s and we strongly encourage readers to wager only what they can afford to lose.
Sky Bet's responsible gambling tools are detailed and if you are concerned about your gambling, please call the National Gambling Helpline on 0808 8020 133, or visit .