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Southampton's point at Watford in midweek saw them edge closer to safety and they can confirm their status with a win over south coast rivals Bournemouth on Saturday.
They were denied all three points in the Vicarage Road clash after Andre Gray's late equaliser for the Hornets, Saints having taken an early lead when Shane Long broke the record for the quickest goal in Premier League history at 7.69 seconds.
Ralph Hasenhuttl got a positive reaction from his side after a disappointing defeat at Newcastle days before and they can guarantee their place in the top-flight by beating an inconsistent Cherries side coasting towards the end of the campaign.
Granted, Eddie Howe's men did thrash Brighton 5-0 in their last away outing, but they have won just twice in their last 11 and have fallen too far adrift to finish in the top half.
Saints can finish strongly with West Ham and Huddersfield to follow this clash, but Hasenhuttl will not be looking beyond Saturday and that focus may well be rewarded.
Since his arrival, Southampton's form at St Mary's has improved dramatically. They have won three of their last four on home soil and that defeat was against title-chasing Liverpool where their performance warranted at least a point.
One player who has raised his game under the Austrian boss is Nathan Redmond and the price on him to get on the score sheet catches the eye. He is around 3/1 anytime and 4/1 in a score-and-win double despite scoring a brace in his last home appearance.
The England winger has been used in a more central role by Hasenhuttl and he has had nine shots in his last three games. He had as many as five in their home win over Fulham a couple of months ago and should partner Danny Ings for this clash.
Against a Bournemouth side which lost to Scott Parker's relegated Fulham last time out, Redmond should fancy his chances.
Super 6 prediction: Southampton 3-1 AFC Bournemouth ()
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Odds correct as of 1430 BST on 25/04/19