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A north London derby with obvious significance due to the fact that once again the two sides are battling it out for a spot in the Premier League's top four.
Tottenham may be facing Juventus in the last 16 of the Champions League on Tuesday, but they cannot afford to take their eye off the ball in the league.
Mauricio Pochettino’s men are fifth going into the match, a point behind Chelsea in fourth, while Arsenal are sixth and five points adrift of the Blues.
It almost goes without saying that key to Spurs' hopes of securing all three points is Harry Kane, who netted his 100th Premier League goal in the recent draw at Liverpool.
Arsenal managed to keep him quiet earlier in the season and Arsene Wenger will be hoping they can do the same again this time around.
The French boss admitted in his press conference that England forward Kane is probably the best striker in Europe, while Kane has said that being rejected by Arsenal as a youngster was "the best thing that ever happened to me".
Considering his impressive record of scoring six times in seven appearances against the Gunners, you would back him to find the back of the net.
All eyes will not just be on Kane though, as Pierre-Emerick Aubameyang makes his first north London derby appearance, fresh from a goal against Everton on his Arsenal bow. With Mesut Ozil and Henrikh Mkhitaryan – who knows the Gabon international’s game inside out – behind him, he should not be short of chances.
This fixture has produced at least two goals in each of the last eight meetings and, given the importance of the three points, attacking options on both sides and the spacious Wembley field, you would expect both teams to score in what should be another highly entertaining derby.
(George Pitts)
Palace just cannot catch a break at the minute when it comes to injuries. Bakary Sako was ruled out for the season last week and that has been followed up by the recent news star man Wilfried Zaha will be out for around a month – on top of Ruben Loftus-Cheek’s long-term setback.
Just as Roy Hodgson's side appeared to be climbing away from the relegation zone, they've been given another hurdle to overcome. They face an Everton side who have themselves slipped back down the table after a brief revival under Sam Allardyce, but vitally they still remain seven points clear of the bottom three.
You would expect both sides to retain their Premier League status come the end of the season, but they both need points on the board sooner rather than later.
Given Palace's injury woes heading to Goodison and their terrible record without Zaha, I'm backing Everton to come away with the victory. They were impressive at home to Leicester, before a shocking performance at Arsenal saw them ship five goals at the Emirates.
Allardyce will no doubt have been working hard on the training ground to bury that performance, as he comes up against another former club.
The Toffees have been struggling with injuries themselves, but Allardyce says the situation is now the best it has been since he replaced Ronald Koeman in November.
Theo Walcott, who came close to scoring on his return to Arsenal, is the danger man after netting a double against the Foxes. The forward is desperate to force his way into Gareth Southgate’s England reckoning for the World Cup and his pace and movement could be too much for a depleted Palace defence to handle.
The clash probably won’t live long in the memory, but the hosts will in all likelihood get the job done.
(GP)
Three points between the sides in the Premier League table, each has recorded one win in their last six and unsurprisingly the layers have this as a pretty close call.
West Ham edge favouritism in the match market, with the draw no bigger than 12/5, and that looks just about fair based on their home form, which isn’t that bad at all in the past couple of months, combined with the visitors' ropy recent away record.
West Ham's 3-2 defeat against Newcastle on December 23 is their most recent loss at the London Stadium, since when they've beaten West Brom (plus Shrewsbury in the FA Cup) and drawn with Bournemouth and Crystal Palace.
David Moyes will have been fuming with how they capitulated at Brighton last weekend after getting level before the break and I'd certainly expect a reaction of some kind, despite the injury situation remaining a problem.
It's obviously early days for Watford boss Javi Gracia but a draw at Stoke and Monday’s 4-1 win over champions Chelsea bodes well for this one, especially as they won the reverse fixture 2-0 earlier in the season.
Former Everton and Barcelona winger Gerard Deulofeu was particularly bright against the Blues and should at least carve out a few opportunities for Troy Deeney and co, though Deulofeu himself has already been well found in the anytime scorer market at no bigger than 7/2 after his strike on Monday.
No goalscorer looks big at 10/1 given how West Ham are likely to play after shipping three last week but neither defence is convincing enough to make me pull the trigger and in short there appears to be more inviting opportunities elsewhere on the day.
(MB)
Posted at 0900 GMT on 09/02/18.