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The clash of the weekend sees the two title favourites face off at Anfield.
After Daniel Sturridge's late equaliser to rescue Liverpool a point at Chelsea last time, Man City regained the lead on goal difference and there will be questions to answer on Sunday.
Can Liverpool topple Man City in the race for the Premier League title? Will Jurgen Klopp's side have the psychological edge after already beating Pep Guardiola's City three times in competitive fixtures in 2018?
Thirteen goals in those three fixtures (one Premier League, two Champions League) just shows how wide-open these all-out attacking sides can be against each other, and it goes without saying that it should be an entertaining watch.
While there are plenty of twists and turns to come in the 2018/19 title race, with Chelsea also looking to have a say, a win for either side would be a significant boost even so early into the season.
The betting shows just how hard it is to call, with Liverpool slight favourites due to their home advantage and that could be key. Jurgen Klopp and Pep Guardiola's attention to detail and meticulous planning means both sides will know exactly what is asked of them with little margin for error. Some top-of-the-table clashes do not always live up to their billing, but this fixture often does. Goals and a home win is preferred - Liverpool to win and BTTS is a best price of 16/5, which looks a perfectly logical conclusion to reach, and a very fair price to boot.
Best bet:
It's rare that a Sky Bet RequestABet is put forward as the best route to take, but this combination at 15/8 looks like brilliant value, as overlooking the match market itself gives you a chance of winning either way. Our Premier League Vitals stats page shows the Reds average five corners per game this season, while City have had nearly twice as much in total, averaging nearly nine per game. These sides are lower down on the disciplinary table but a match of this pace and magnitude should surely conjure a yellow card for each team.
Scorer:
Make it a South American double. There are some eye-catching odds in the goalscorer markets due to this match being such a close call. Mo Salah still looks out of sorts and Roberto Firmino has been their star forward so far this season with four goals and two assists. The Brazilian is without a strike in four games now and he has previous against City's defence, scoring twice against them last season. Meanwhile, Sergio Aguero has started the season really well with five Premier League goals and two assists and he has yet to score at Anfield - but City's all-time top scorer can break his duck at the ground and the odds for both of them presents good value. For greater odds, set pieces could be key and Virgil van Dijk is 14/1 to score anytime for the hosts.
Sporting Life RequestABet:
Odds correct as of 2150 BST on 05/10/18