So, do City fans have reasons to hope when going to the Etihad? Or should Liverpool fans take the trip along the M62 fully confident of completing the job?
Well, with the two teams involved being so exciting to watch going forward, and so fragile at times at the back, anything really could happen. But what are the main factors to consider for the big game?
Despite the big lead Liverpool have piled up, the first goal is still absolutely crucial on Tuesday, for both sides. Should the visitors score first, that then leaves City needing to score five due to away goals, but if Guardiola’s side can go ahead early then all of a sudden the mood will change.
Liverpool may have injury problems, but their 0-0 draw at Goodison gave them a rather sedate run-out and allowed Klopp to try a new formation and crucially rest his starting full-backs Andrew Robertson and Trent Alexander-Arnold, who both starred last week.
By contrast to their largely non-descript lunchtime game, City endured a nightmare against arch rivals Manchester United as they let a two-goal lead slip during a dramatic second-half collapse.
City should have been out of sight after a dominant first half, and while that 45 minutes will have pleased Guardiola, Klopp will have enjoyed the second half goals United scored as City looked far from comfortable at the back.
That should give Klopp huge belief that his side can score - they’ve only failed to hit the net seven times this season – and City’s defence on Saturday will have made him and his team aware that even if City score themselves there’s always a chance of finding a way through.
Odds correct as of 1300 BST 09/04/2018.