Let's start with their overall record in games against each other. This obviously takes into account Liverpool's glory years of dominance and that may be something that City go on to emulate over the next few years under Pep Guardiola and with the fortunes he's being back with.
Their two league meetings have been eventful, City winning 5-0 against ten-men at the Etihad before a thrilling 4-3 Liverpool win at Anfield in January. City have won just one of the last eight meetings in 90 minutes - although they crucially won the Capital One Cup on penalties.
City's record at Anfield is pretty grim, they've not won there in 15 years and 16 games, but this being European competition winning the first leg is not all-important - a 4-3 defeat like January would make Guardiola confident of getting through from the second leg at home.
The main danger comes from a bit deeper for City in the form of David Silva and Kevin De Bruyne, who keep the ball wonderfully and then supply the bullets for Leroy Sane, Raheem Sterling and either Gabriel Jesus or Sergio Aguero.
Neither defence seems able to contain the opposing attack, so it could also be a case of who can score more in a goal fest in both matches.
Neither manager also seems able, or more importantly willing, to compromise on their attacking philosophy to try and shut up shop at the back and try to keep it tight as these European games so frequently are - this tie should be a thriller.
Making life even tougher for Klopp is the injury to Emre Can, who played well against City in the 4-3 win in January, while Adam Lallana is out again further depleting Klopp's options.
Three of Jordan Henderson, Gini Wijnaldum, James Milner and Alex Oxlade-Chamberlain will be picked for the game, with the fourth no doubt given a run out off the bench.
Whoever Klopp plays they need to try and control midfield as much as is possible against this City team to avoid being overrun - you'll never keep Silva and De Bruyne out of a game such is their quality, but reducing their impact will give the Reds a huge chance of springing an upset.
Last updated at 1300 BST 03/04/2018.