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A return to the Emirates offers up a great chance for Arsenal to boost their top four hopes against a Palace side who now feel they're safe from the threat of relegation.
Unai Emery's side have only lost once in the league on home soil this season and only Liverpool and Man City have accrued more home points so they'll fancy another three points here despite the Eagles being a better team away from home this campaign.
Palace will still offer a threat in the pace and trickery of Zaha and Townsend, especially against a Gunners defence that is far from impressive even at home, but going forward they play some wonderful stuff at the Emirates and Palace would need to put in a big shift to keep them out.
Of course, Thursday's trip to Naples in the Europa League may have an effect on Arsenal's legs, but at home there's enough to like about their home form to see them winning this one.
Prediction: Arsenal 2-1 Crystal Palace
It may be tough, especially early on as Arsenal try and get Thursday's trip to Italy out of their legs, but they need this more for their top four hopes and that, along with their superb attacking options, means they can just about get the job done.
Best bet:
Arsenal have won ten in a row at the Emirates, but Palace are the seventh best away team in the league and have scored in nine of their last ten road trips so there's no reason why they can't pierce this leaky rearguard.
Goals:
Pierre-Emerick Aubameyang has scored more Premier League London derby goals than any other player this season with 6, and he'll bag his seventh here as he opens the scoring for the hosts.
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