Not only is it a chance for Aguero to say farewell, he's also chasing another record. He needs one goal to equal Wayne Rooney's record of 183 goals scored for one club in the Premier League - with two goals enough to claim sole ownership.
If, and it still feels like a big if, Aguero is involved for City on Sunday, they will surely be looking for him to finish with a goal. There may be some sentimental attachment to this selection but he could be a huge differential player if he is involved - any opportunity to score and City will want him to have it.
After all, this is a City team scoring plenty and they should go fairly strong to try and build some momentum for the Champions League final. Having Aguero leading the line will see him have numerous opportunities to score against an Everton team who have become really hot and cold.
We wait and see what Guardiola says on Aguero's fitness and his chances of being involved, but if he does pass the tests, it could be a move that pays off in a big way - even if he does carry a big price tag on both games.
That means that his return over the last five games on Sky has been 32 points while he's hit 29 points over the same period on FPL. Against a Palace side whose only clean sheet in their last eight has come against bottom of the league Sheffield United, Firmino will fancy his chances.
's statistics also show that over the past five games, only Chris Wood (36), Christian Benteke (32) and Kelechi Iheanacho (32) have gained more points than Firmino, while the Liverpool man has the highest expected assists (xA) figure of any forward with 1.93.
That ultimately placed him second in their Expected Fantasy Premier League points (xFPL) charts to Benteke among forwards.
This isn't to say that it's worth taking out Salah to get him in, but his position as a forward on the FPL game while Salah sits in midfield maximises the potential Liverpool attacking output. The Reds have, of course, scored in 11 of their last 12 games in all competitions.
It's also worth noting that Fantasy Football Fix predicts that Salah's price will rise before the FPL gameweek gets underway so potential budget restrictions may mean Firmino is the better option.
Liverpool know the importance of three points here with victory nailing down a top-four spot and they will have fans in Anfield backing them across the line. His form may have gone under the radar and that makes Firmino a strong differential pick for Gameweek 38.
Delving into Infogol's statistics really highlights just how much of an impact Willock has had since joining Newcastle. The stand out one is that his expected goals figure per 95 minutes is 0.43. The top line is that this is very good as it has the midfielder just outside of the top 20 in the league since the start of February.
It's the same as Raheem Sterling and marginally better than both Jamie Vardy (0.42) and Timo Werner (0.41). It's also a higher average than Southampton striker Danny Ings (0.39) and Manchester United forward Edinson Cavani (0.37).
His form since Gameweek 30 has been exceptional, with Fantasy Football Fix highlighting that he sits seventh for points returned over that period. However, he has played fewer games than those above him and yet no midfielder can better his six goals scored - that is level with Matheus Pereira and Mason Greenwood.
At the time of writing, the same website reports that 37,989 have transferred in Willock so he should be one of the most moved-for players on the FPL game for Gameweek 38 - we await to see how serious a potential injury picked up in the win over Sheffield United is.
With his selection rate at a tiny 0.31% on Sky, and just 2.3% of FPL players owning him, Willock will remain a differential player going into the final day of the season and another goal will provide plenty of points that many others won't have.