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Will any of the Premier League big boys suffer an FA Cup upset this weekend?
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Spurs return to St Mary's less than a month after losing to Ralph Hasenhuttl's men and they will be seeking revenge.
With Jose Mourinho making no bones about his desire to go far in this competition, it is hard to look away from the visitors for this one.
Another interesting contest will be Mourinho coming face to face with the Southampton coaching member of staff who he called an 'idiot' after his booking.
With his intentions (we actually tipped them in our outright preview) he should field a strong side and, even though Hasenhuttl's side have improved drastically in the last couple of months, they still cannot afford to take their eye off the ball in the league.
Spurs want success and Mourinho wants it fast, so two goals for the hosts - with Dele Alli, Heung-min Son and co. stepping up in Harry Kane's absence - en route to the fifth round at a tasty 11/10 price is worth taking for us.
Best bet:
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