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It really is make or break for these teams and Chelsea arguably have far more to lose in this huge final.
Manchester United may be slightly disappointed with their campaign, but a second-place finish in the Premier League for the first time in the post-Sir Alex Ferguson era shows the progress Jose Mourinho is making at Old Trafford.
The Red Devils won this competition in 2015/16 under Louis van Gaal and they are 7/4 favourites to secure the trophy in 90 minutes on Saturday. It would be a third trophy for Mourinho in two seasons at the club, providing them with a great platform to build on with the league title in their sights next year.
They have been pretty convincing in the FA Cup this year, avoiding replays as they beat Derby, Yeovil, Huddersfield, Brighton (all four with clean sheets) and Tottenham en route to the final.
Chelsea, meanwhile, were forced to a replay with Norwich which went to extra-time and penalties in the third round, before beating Newcastle, Hull, Leicester – after extra-time – and Southampton.
Speculation is rife the Wembley date will be Antonio Conte's last after two years as head coach, with the Italian’s body language in recent weeks suggesting that could well be the case.
He will be hoping to go out on a high with his side, while going one better than last year after losing in the final to Arsenal.
Manchester United to win in 90 minutes and BTTS at 5/1
Romelu Lukaku to score and Manchester United to win in 90 minutes at 4/1
Last updated at 1545 BST 17/05/2018.