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A clash in a competition few of these teams will want to think about at this stage of the season.
It is not televised, but rescheduled for Thursday because of Pep Guardiola's side's fixture schedule - they have four games in 10 days across the Premier League, Carabao Cup and Champions League.
It is sandwiched between Monday's win at Tottenham and Sunday's match at home to Southampton, so expect the holders to make wholesale changes.
Best bet:
OK so we won't be millionaires but finding anything like value in a game where the hosts are 1/10 is always a tough assignment, especially when we're guessing on the line-up. City have only failed to cover this line once at home this season and regularly get into double figures for corners at the Etihad. When the two sides met in the league it was 10-4 in City's favour.
Goalscorer:
It's tough knowing exactly which way Guardiola will go but the Belgian is still being nursed back to full fitness and after a substitute appearance at Tottenham a start against Fulham would be another step in the right direction and as he's usually involved in everything he's a decent shout to grab a goal.
RequestABet:
Again we're not getting too rich but again it's a tough one to call with selection issues at the heart of it. Corners and goals should be easy enough to bring up but going for the two players most likely to play, and score, is the tougher prospect.
Odds correct as of 1600 GMT on 31/10/18