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It looks like job done for Valencia after that commanding victory away last week, especially given Villarreal have won just two of 13 away from home in La Liga, although in the Europa League they are unbeaten in five.
It would take a huge turnaround here though for them to even have a sniff and the more probable outcome is that Valencia canter to qualification and most likely win the match itself.
Best Bet:
Odds correct as of 1120 BST on 17/04/19