It has the feel of the biggest Sheffield derby in a number of years given the position of both sides and the time of season.
United are after the title, while a resurgent Wednesday are hopeful of reaching the play-offs after an upturn in results following Steve Bruce's arrival.
The previous two meetings have finished goalless, while the game at Hillsborough at the start of last season saw the Blades come out on top in a six-goal thriller. United will also feel that they should have won the two games at Bramall Lane.
Best bets:
Odds correct at 1150 GMT (04/03/19)