Match-winner Lozano's goal came when he finished a Mexican break by drilling a low shot past Manuel Neuer.
Germany took too long to get going and lacked the poise the rest of the world has grown accustomed to seeing on this stage from Die Mannschaft.
They have been battering teams in World Cup openers for as long as any of the players on this pitch could remember. Their last defeat in a first game was to Algeria in 1982, and since then they had averaged three and a half goals, but this was not to be as Mexico stole the headlines.
Odds correct as of 1750 BST 17/06/18